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Acinetobacter baumannii 대표 이미지

영문 설명
출처: Wikipedia
Acinetobacter baumannii is a typically short, almost round, rod-shaped (coccobacillus) Gram-negative bacterium. It can be an opportunistic pathogen in humans, affecting people with compromised immune systems, and is becoming increasingly important as a hospital-derived (nosocomial) infection. While other species of the genus Acinetobacter are often found in soil samples (leading to the common misconception that A. baumannii is a soil organism, too), it is almost exclusively isolated from hospital environments. Although occasionally it has been found in environmental soil and water samples, its natural habitat is still not known. Bacteria of this genus lack flagella, whip-like structures many bacteria use for locomotion, but exhibit twitching or swarming motility. This may be due to the activity of type IV pili, pole-like structures that can be extended and retracted. Motility in A. baumannii may also be due to the excretion of exopolysaccharide, creating a film of high-molecular-weight sugar chains behind the bacterium to move forward. Clinical microbiologists typically differentiate members of the Acinetobacter genus from other Moraxellaceae by performing an oxidase test, as Acinetobacter spp. are the only members of the Moraxellaceae to lack cytochrome c oxidases. A. baumannii is part of the ACB complex (A. baumannii, A. calcoaceticus, and Acinetobacter genomic species 13TU). Members of the ACB complex are difficult to determine the specific species and comprise the most clinically relevant members of the genus. A. baumannii has also been identified as an ESKAPE pathogen (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), a group of pathogens with a high rate of antibiotic resistance that are responsible for the majority of nosocomial infections. Colloquially, A. baumannii is referred to as 'Iraqibacter' due to its seemingly sudden emergence in military treatment facilities during the Iraq War. It has continued to be an issue for veterans and soldiers who served in Iraq and Afghanistan. Multidrug-resistant A. baumannii has spread to civilian hospitals in part due to the transport of infected soldiers through multiple medical facilities. Due to the prevalence of infections and outbreaks caused by multidrug-resistant A. baumannii, few antibiotics are effective for treating infections caused by this pathogen. To overcome this problem, knowledge of the pathogenesis, antibiotic resistance mechanisms, and prospective treatment options of A. baumannii is important. Vrulence factors and determinants - Many microbes, including A. baumannii, have several properties that allow them to be more successful as pathogens. These properties may be virulence factors such as toxins or toxin delivery systems which directly affect the host cell. They may also be virulence determinants, which are qualities contributing to a microbe's fitness and allow it to survive the host environment, but that do not affect the host directly. These characteristics are just some of the known factors which make Acinetobacter baumannii effective as a pathogen: Capsule - Many virulent bacteria possess the ability to generate a protective capsule around each individual cell. This capsule, made of long chains of sugars, provides an extra physical barrier between antibiotics, antibodies, and complement. The association of increased virulence with presence of a capsule was classically demonstrated in Griffith's experiment. A gene cluster responsible for secretion of the polysaccharide capsule has been identified and shown to inhibit the antibiotic effect of complement when grown on ascites fluid. A decrease in killing associated with loss of capsule production was then demonstrated using a rat virulence model. OMPA - Adhesion can be a critical determinant of virulence for bacteria. The ability to attach to host cells allows bacteria to interact with them in various ways, whether by type III secretion system or simply by holding on against the prevailing movement of fluids. Outer membrane protein A has been shown to be involved in the adherence of A. baumannii to epithelial cells. This allows the bacteria to invade the cells through the zipper mechanism. The protein was also shown to localize to the mitochondria of epithelial cells and cause necrosis by stimulating the production of reactive oxygen species. Antibiotic resistance - AbaR resistance islands - Pathogenicity islands, relatively common genetic structures in bacterial pathogens, are composed of two or more adjacent genes that increase a pathogen's virulence. They may contain genes that encode toxins, coagulate blood, or as in this case, allow the bacteria to resist antibiotics. AbaR-type resistance islands are typical of drug-resistant A. baumannii, and different variations may be present in a given strain. Each consists of a transposon backbone of about 16.3 Kb that facilitates horizontal gene transfer. Transposons allow portions of genetic material to be excised from one spot in the genome and integrate into another. This makes horizontal gene transfer of this and similar pathogenicity islands more likely because, when genetic material is taken up by a new bacterium, the transposons allow the pathogenicity island to integrate into the new microorganism's genome. In this case, it would grant the new microorganism the potential to resist certain antibiotics. AbaRs contain several genes for antibiotic resistance, all flanked by insertion sequences. These genes provide resistance to aminoglycosides, aminocyclitols, tetracycline, and chloramphenicol. Efflux pumps - Efflux pumps are protein machines that use energy to pump antibiotics and other small molecules that get into the bacterial cytoplasm and the periplasmic space out of the cell. By constantly pumping antibiotics out of the cell, bacteria can increase the concentration of a given antibiotic required to kill them or inhibit their growth when the target of the antibiotic is inside the bacterium. A. baumannii is known to have two major efflux pumps which decrease its susceptibility to antimicrobials. The first, AdeB, has been shown to be responsible for aminoglycoside resistance. The second, AdeDE, is responsible for efflux of a wide range of substrates, including tetracycline, chloramphenicol, and various carbapenems. Small RNA - Bacterial small RNAs are noncoding RNAs that regulate various cellular processes. Three sRNAs, AbsR11, AbsR25, and AbsR28, have been experimentally validated in the MTCC 1425 (ATCC15308) strain, which is a (multidrug-resistant) strain showing resistance to 12 antibiotics. AbsR25 sRNA could play a role in the efflux pump regulation and drug resistance. Beta-lactamase - A. baumannii has been shown to produce at least one beta-lactamase, which is an enzyme responsible for cleaving the four-atom lactam ring typical of beta-lactam antibiotics. Beta-lactam antibiotics are structurally related to penicillin, which inhibits synthesis of the bacterial cell wall. The cleaving of the lactam ring renders these antibiotics harmless to the bacteria. The beta-lactamase OXA-23 was found to be flanked by insertion sequences, suggesting it was acquired by horizontal gene transfer. Biofilm formation - A. baumannii has been noted for its apparent ability to survive on artificial surfaces for an extended period of time, therefore allowing it to persist in the hospital environment. This is thought to be due to its ability to form biofilms. For many biofilm-forming bacteria, the process is mediated by flagella. However, for A. baumannii, this process seems to be mediated by pili. Further, disruption of the putative pili chaperone and usher genes csuC and csuE were shown to inhibit biofilm formation. The formation of biofilms has been shown to alter the metabolism of microorganisms within the biofilm, consequently reducing their sensitivity to antibiotics. This may be because fewer nutrients are available deeper within the biofilm. A slower metabolism can prevent the bacteria from taking up an antibiotic or performing a vital function fast enough for particular antibiotics to have an effect. They also provide a physical barrier against larger molecules and may prevent desiccation of the bacteria. Signs and symptoms of infection - A. baumannii is an opportunistic bacterium with a range of different diseases, each with their own symptoms. Some possible types of A. baumannii infections include: Pneumonia Bloodstream Infections Meningitis Wound and surgical site infections, including flesh eating bacterium necrotizing fasciitis Urinary Tract Infections Symptoms of A. baumannii infections are often indistinguishable from other opportunistic infections caused by other opportunistic bacteria - including Klebsiella pneumoniae and Streptococcus pneumoniae. Symptoms of A. baumannii infections in turn range from fevers and chills, rash, confusion and/or altered mental states, pain or burning sensations when urinating, strong urge to urinate frequently, sensitivity to bright light, nausea (with or without vomiting), muscle and chest pains, breathing problems, and cough (with or without yellow, green, or bloody mucus). In some cases, A. baumannii may present no infection or symptoms, as with colonizing an open wound or tracheostomy site. Treatment - Because most infections are now resistant to multiple drugs, determining what susceptibilities the particular strain has is necessary to for treatment to be successful. Traditionally, infections were treated with imipenem or meropenem, but a steady rise in carbapenem-resistant A. baumannii has been noted. Consequently, treatment methods often fall back on polymyxins, particularly colistin. Colistin is considered a drug of last resort because it often causes kidney damage, among other side effects. Prevention methods in hospitals focus on increased hand-washing and more diligent sterilization procedures. Traumatic injuries, like those from improvised explosive devices, leave large open areas contaminated with debris that are vulnerable to becoming infected with A. baumannii. The logistics of transporting wounded soldiers result in patients visiting several facilities where they may acquire A. baumannii infections. Occurrence in veterans injured in Iraq and Afghanistan - Soldiers in Iraq and Afghanistan are at risk for traumatic injury due to gunfire and improvised explosive devices. Previously, infection was thought to occur due to contamination with A. baumannii at the time of injury. Subsequent studies have shown, although A. baumannii may be infrequently isolated from the natural environment, the infection is more likely nosocomially acquired, likely due to the ability of A. baumannii to persist on artificial surfaces for extended periods, and the several facilities to which injured soldiers are exposed during the casualty-evacuation process. Injured soldiers are first taken to level-I facilities, where they are stabilized. Depending on the severity of the injury, the soldiers may then be transferred to a level-II facility, which consists of a forward surgical team, for additional stabilization. Depending on the logistics of the locality, the injured soldiers may transfer between these facilities several times before finally being taken to a major hospital within the combat zone (level III). Generally after 1–3 days, when the patients are stabilized, they are transferred by air to a regional facility (level IV) for additional treatment. For soldiers serving in Iraq or Afghanistan, this is typically Landstuhl Regional Medical Center in Germany. Finally, the injured soldiers are transferred to hospitals in their home country for rehabilitation and additional treatment. This repeated exposure to many different medical environments seems to be the reason A. baumannii infections have become increasingly common. Multidrug-resistant A. baumannii is a major factor in complicating the treatment and rehabilitation of injured soldiers, and has led to additional deaths. Incidence in hospitals - Being referred to as an opportunistic infection, A. baumanii infections are highly prevalent in hospital settings. A. baumanii poses very little risk to healthy individuals, however, factors that increase the risks for infection include Having a weakened immune system Chronic Lung Disease Diabetes Lengthened hospital stays Illness that requires use of a hospital ventilator Having an open wound treated in a hospital Treatments requiring invasive devices like urinary catheters A. baumanii can be spread through direct contact with surfaces, objects, and the skin of contaminated persons. The importation of A. baumannii and subsequent presence in hospitals has been well documented. A. baumannii is usually introduced into a hospital by a colonized patient. Due to its ability to survive on artificial surfaces and resist desiccation, it can remain and possibly infect new patients for some time. A baumannii growth is suspected to be favored in hospital settings due to the constant use of antibiotics by patients in the hospital. Acinetobacter can be spread by person-to-person contact or contact with contaminated surfaces. Acinetobacter can enter through open wounds, catheters and breathing tubes. In a study of European intensive care units in 2009, A. baumannii was found to be responsible for 19.1% of ventilator-associated pneumonia cases. A 2013 Indonesian study showed that neonatal infections with A. baumanii were due to the same strains of the bacteria found in the hospital in which the neonates had spent their earliest days. These strains were found on hard surfaces as well as on the hands of medical personnel.
국문 설명
출처: Wikipedia
Acinetobacter baumannii는 감마프로테오박테리아에 속하며, 짧고 둥근 막대 모양의 그람음성 세균이다. 인간에게는 기회주의적 병원균이며, 면역시스템이 손상된 사람들에게는 병원내 감염균으로서 점차 중요성이 더해 가고 있다. Acinetobacter 속의 다른 종들은 대부분 토양으로부터 분리되었으나, A. baumannii 는 유일하게 병원환경으로부터 분리된 종이다. 이 속의 균주는 편모가 없으며 채찍과 같은 구조를 통해 운동력을 발휘하는데 확장 및 수축될 수 있는 극형 구조인 IV형 섬모의 활동으로 운동하며, 또한 다당류를 분비하여 박테리아 뒤에 고분자 당사슬 막을 만들어 앞으로 나아갈 수 있다. 산화효소 검사를 통하여 Acinetobacter 속 (Acinetobacter spp.)을 Moraxellaceae 로부터 구별하며, Acinetobacter 속은 Moraxellaceae에서 유일하게 시토크롬 C 산화효소가 결핍되어 있다. A. baumannii는 항생제 저항성이 높은 병원균 그룹인 ESKAPE 병원균 (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa 및 Enterobacter species)으로서 대부분의 병원감염과 관련되어 있다. A. baumannii는 이라크 전쟁 중 병원에서 발생하게 되는 갑작스런 출현로 인해 'Iraqibacter'라고 불리며 이라크와 아프가니스탄 참전 병사들에게 지속적인 문제가 되고 있다. 다제 내성 A. baumannii는 여러 의료시설을 통해 감염된 병사에 의해 일부 민간 병원으로도 퍼지게 되었으며 A. baumannii 에 의한 감염 및 병원균에 대한 항생제는 거의 없는 실정이다. 악성 세균은 각각의 개별 세포 주위에 보호 캡슐을 생성하는 능력을 가지고 있으며, 이 캡슐은 긴 사슬의 당으로 만들어져 항생제, 항체 및 보완제 사이에 추가적인 물리적 장벽을 만든다. 병독성과 캡슐의 존재와의 연관성은 그리피스의 실험에서 입증되어, 다당류 캡슐의 분비를 담당하는 유전자 군이 확인되었으며 복수 세포에서 성장할 때 보체의 항생제 효과를 억제하는 것으로 나타났다. 접착력은 박테리아에 대한 독성의 결정적인 요인이 되며, 숙주 세포에 붙어 박테리아가 다양한 방식으로 상호 작용할 수 있게 한다. 외부 막 단백질 A는 A. baumanni가 상피세포에 부착하여 지퍼 메커니즘을 통해 세포에 침투하게 하며 상피세포의 mitochondria에 국부적으로 작용하여 반응성 산소종의 생산을 자극하여 괴사를 일으키는 원인으로 작용하기도 한다. A. baumannii 감염의 증상은 발열과 오한, 발진 또는 정신 상태의 변화, 소변을 볼 때의 통증이나 타는 듯한 느낌, 자주 소변을 보는 강한 충동, 밝은 빛에 대한 감수성, 메스꺼움, 근육 및 가슴 통증, 호흡 곤란 및 기침 (황색, 녹색 또는 피가 묻은 점액이 있음) 등이 있다. 경우에 따라서는 A. baumannii 가 감염이나 증상을 나타내지 않을 수도 있으나, 개방 상처 또는 기관 절개 부위에 집락을 형성하는 경우도 있다. 기회주의 감염으로 불리는 A. baumanii 감염은 병원 환경에서 매우 보편적으로 일어나며 건강한 사람에게는 위험이 거의 없지만, 감염의 위험을 증가시키는 요인으로서는 약화된 면역 체계, 만성 폐 질환, 당뇨병, 병원 체류연장, 병원 호흡기 사용, 병원에서 입은 상처, 요도 카테터와 같은 침습적인 장치가 필요한 치료 등이 있다. A. baumanii는 오염된 물체 및 피부와의 직접적인 접촉에 의하여 퍼지게 된다.
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